Work

The role of DNA methylation on gene expression in actue lymphoblastic leukemia

Year: 2010

Type: other

Abstract: Epigenetic modification of the genome has more influence on gene expression than DNA sequence alone. DNA hypermethylation and deacetylation of histone complexes has been shown to down regulate expression of associated genes. These epigenetic modifications may play an important role in the pathogenesis of cancer. Demethylation agents and histone deacytlase inhibitors used to restore gene activity to previous levels could lead to development of novel anti-cancer drugs.

Source: MOspace Institutional Repository (University of Missouri)

Authors: James Langworthy, Kristen H. Taylor

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2885443288

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