Work

Influences of Nanocarrier Morphology on Therapeutic Immunomodulation

Year: 2018

Type: article

Abstract: Nanomaterials provide numerous advantages for the administration of therapeutics, particularly as carriers of immunomodulatory agents targeting specific immune cell populations during immunotherapy. While the physicochemical characteristics of nanocarriers have long been linked to their therapeutic efficacy and applications, focus has primarily been placed on assessing influences of size and surface chemistry. In addition to these materials properties, the nanostructure morphology, in other words, shape and aspect ratio, has emerged as an equally important feature of nanocarriers that can dictate mechanisms of endocytosis, biodistribution and degree of cytotoxicity. In this review, we will highlight how the morphological features of nanostructures influence the immune responses elicited during therapeutic immunomodulation.

Source: Nanomedicine

DOI: 10.2217/nnm-2018-0052

Authors: Molly Frey, Sharan Bobbala, Nicholas Karabin, Evan Scott

Institutions: Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chemistry of Life Processes Institute

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences