Work

Impaired transmissibility of atypical prions from genetic CJD G114V

Year: 2018

Type: article

Abstract: OBJECTIVE: -G114V variant. METHODS: We performed genetic, histologic, and molecular studies, combined with in vivo transmission studies and in vitro replication studies, to characterize this genetic prion disease. RESULTS: type 2 (∼19 kDa) was selectively amplified. CONCLUSIONS: AAAAGA-120) plays an important role in prion conformation and propagation.

Source: Neurology Genetics

DOI: 10.1212/nxg.0000000000000253

Authors: Ignazio Cali, Fadi Mikhail, Kefeng Qin, Crystal Gregory, Ani Solanki, Manuel Camacho Martinez, Lili Zhao, Brian Appleby, Pierluigi Gambetti, Eric Norstrom, James A. Mastrianni

Institutions: DePaul University, University of Chicago, Case Western Reserve University

Language: English

Topic: Prion Diseases and Protein Misfolding

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,300

Funders: National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke

Awards: G2170718992, G7223502298, Training Program in Neuroengineering and Medicine

OpenAlex ID: W2885713090

FWCI: 0.392

Cites: 44

Cited by: 7

Related to: 10