Work

14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gαi–AlF4− signaling complex and RGS14 nuclear localization

Year: 2018

Type: article

Abstract: and nuclear import, while leaving the function of other RGS14 domains intact. Ongoing studies will further elucidate the physiological function of this interaction between RGS14 and 14-3-3γ, providing insight into the functions of both RGS14 and 14-3-3 in their roles in modulating synaptic plasticity in the hippocampus.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.ra118.002816

Authors: Kyle J. Gerber, Katherine E. Squires, John R. Hepler

Institution: Emory University

Language: English

Topic: 14-3-3 protein interactions

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke