Work

Synthetic Ingenols Maximize Protein Kinase C-Induced HIV-1 Latency Reversal

Year: 2018

Type: article

Abstract: T cells from aviremic participants. Among the synthetic ingenols that we produced, we identified several compounds that demonstrate high efficacy and represent promising leads as latency reversal agents for HIV-1 eradication.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01361-18

Authors: Adam M. Spivak, Racheal A. Nell, Mark Petersen, Laura Martins, Paul Sebahar, Ryan E. Looper, Vicente Planelles

Institution: University of Utah

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Doris Duke Charitable Foundation, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: G1222720780, BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy, G3245697546, Preclinical Development of Ingenol and HDACi Toward HIV Eradication, Utah Center for Clinical and Translational Science, Development of SMAC mimetics as latency-reversing agents

OpenAlex ID: W2885856329

FWCI: 1.441

Cites: 62

Cited by: 24

Related to: 10