Using routinely collected data to understand and predict adverse outcomes in opioid agonist treatment: Protocol for the Opioid Agonist Treatment Safety (OATS) Study
Year: 2018
Type: article
Abstract: INTRODUCTION: North America is amid an opioid use epidemic. Opioid agonist treatment (OAT) effectively reduces extramedical opioid use and related harms. As with all pharmacological treatments, there are risks associated with OAT, including fatal overdose. There is a need to better understand risk for adverse outcomes during and after OAT, and for innovative approaches to identifying people at greatest risk of adverse outcomes. The Opioid Agonist Treatment and Safety study aims to address these questions so as to inform the expansion of OAT in the USA. METHODS AND ANALYSIS: This is a retrospective cohort study using linked, routinely collected health data for all people seeking OAT in New South Wales, Australia, between 2001 and 2017. Linked data include hospitalisation, emergency department presentation, mental health diagnoses, incarceration and mortality. We will use standard regression techniques to model the magnitude and risk factors for adverse outcomes (eg, mortality, unplanned hospitalisation and emergency department presentation, and unplanned treatment cessation) during and after OAT, and machine learning approaches to develop a risk-prediction model. ETHICS AND DISSEMINATION: This study has been approved by the Population and Health Services Research Ethics Committee (2018HRE0205). Results will be reported in accordance with the REporting of studies Conducted using Observational Routinely-collected health Data statement.
Source: BMJ Open
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,839
Funders: Australian Government, National Institute for Health Research Health Protection Research Unit, National Institute for Health and Care Research, University of New South Wales, Medical Research Council, National Health and Medical Research Council, National Drug and Alcohol Research Centre, National Institute on Drug Abuse
Awards: Increasing the capacity of community pharmacy for screening, brief intervention and referral for treatment of pharmaceutical opioid use disorders, Evaluating the impact of opiate substitution treatment on drug related deaths in the population: a natural experiment using primary care, other drug treatment databases & model projections, NIHR Senior Investigator Award, G6590591483, Using existing data to understand and ameliorate risk in opioid agonist therapy, Increasing global and national knowledge about illicit drug use, harms and effective interventions, Increasing knowledge about substance use, mental health and harms, and interventions to prevent and reduce harm
OpenAlex ID: W2886079206