GlucoCEST imaging with on‐resonance variable delay multiple pulse (onVDMP) MRI
Year: 2018
Type: article
Abstract: PURPOSE: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. METHODS: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. RESULTS: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. CONCLUSIONS: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.
Source: Magnetic Resonance in Medicine
DOI: 10.1002/mrm.27364
Authors: Xiang Xu, Jiadi Xu, Kannie W.Y. Chan, Jing Liu, Huanling Liu, Yuguo Li, Lin Chen, Guanshu Liu, Peter C.M. van Zijl
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Novel approaches for CEST labeling, detection, quantification and translation, JHU ICMIC Program, Development and Translation of D-glucose as an MRI Contrast Agent for Multiple Sclerosis, MRI Assessment of Glucose Metabolism in Brain Tumor Using GlucoCEST, Development and Translation of D-glucose as a Diagnostic Agent for MRI of Cancer
OpenAlex ID: W2886280457