Work

Radiosynthesis and validation of [ Carboxy ‐11C]4‐ A minobenzoic acid ([11 C ] PABA ), a PET radiotracer for imaging bacterial infections

Year: 2018

Type: article

Abstract: C] PABA is described in detail, and a quality control summary of three validation productions is presented. The results indicate that the radiotracer product can be produced in good radiochemical yield (14% at end-of-synthesis (EOS)) at high specific activity (molar activity 11 Ci/μmole EOS; 407 GBq/μmole) and high chemical and radiochemical purity as a sterile, pyrogen-free solution suitable for injection conforming to current Good Manufacturing Practice (cGMP) requirements.

Source: Journal of Labelled Compounds and Radiopharmaceuticals

DOI: 10.1002/jlcr.3674

Authors: Daniel P. Holt, Alvin S. Kalinda, Lauren E. Bambarger, Sanjay K. Jain, Robert F. Dannals

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering