Work

In vivo detection of optically-evoked opioid peptide release

Year: 2018

Type: article

Abstract: Though the last decade has seen accelerated advances in techniques and technologies to perturb neuronal circuitry in the brain, we are still poorly equipped to adequately dissect endogenous peptide release in vivo. To this end we developed a system that combines in vivo optogenetics with microdialysis and a highly sensitive mass spectrometry-based assay to measure opioid peptide release in freely moving rodents.

Source: eLife

DOI: 10.7554/elife.36520

Authors: Ream Al-Hasanil, Jenny-Marie T. Wong, Omar S. Mabrouk, Jordan G. McCall, Gavin P. Schmitz, Kirsten A. Porter-Stransky, Brandon J. Aragona, Robert T. Kennedy, Michael R. Bruchas

Institutions: University of Health Sciences and Pharmacy, Washington University in St. Louis, University of Michigan, University of Washington

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: University of Michigan, Hope Center for Neurological Disorders, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering

Awards: G1235557982, G1517991296, G2785304089, G2884414116, G2930930757, Postdoctoral Training in the Biology of Drug Abuse, DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCE, G4616948919, G4902911736, In vivo chemical monitoring using capillary separations, G758343326, G8273426055, G991713089

OpenAlex ID: W2886655868

FWCI: 3.301

Cites: 35

Cited by: 80

Related to: 10