Work

Intraoperative fluorescence imaging in thoracic surgery

Year: 2018

Type: article

Abstract: Intraoperative fluorescence imaging (IFI) can improve real‐time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow®) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor‐targeted near‐infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.

Source: Journal of Surgical Oncology

DOI: 10.1002/jso.25149

Authors: Andrew D. Newton, Jarrod D. Predina, Shuming Nie, Philip S. Low, Sunil Singhal

Institutions: University of Pennsylvania, University of Illinois Urbana-Champaign, Purdue University West Lafayette

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, NIH Blueprint for Neuroscience Research