Work

Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors

Year: 2018

Type: article

Abstract: genes and an association with poor patient outcome in multiple types of cancer, and depletion of TLK activity leads to increased replication stress and DNA damage in a panel of cancer cells. Our results reveal a critical role for TLKs in chromatin replication and suppression of replication stress and identify a synergistic lethal relationship with checkpoint signaling and PARP that could be exploited in treatment of a broad range of cancers.

Source: Science Advances

DOI: 10.1126/sciadv.aat4985

Authors: Sung-Bau Lee, Sandra Segura-Bayona, Marina Villamor-Payà, Giulia Saredi, Matthew A. M. Todd, Camille Stephan-Otto Attolini, Ting-Yu Chang, Travis H. Stracker, Anja Groth

Institutions: University of Copenhagen, Taipei Medical University, Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Novo Nordisk Foundation

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

Funders: Ministry of Science and Technology, Institute for Research in Biomedicine, Centres de Recerca de Catalunya, European Commission, National Research Foundation, Danmarks Grundforskningsfond, Ministerio de Economía y Competitividad, Lundbeckfonden, Novo Nordisk, Ministry of Science and Technology, Taiwan, Taipei Medical University, H. Lundbeck A/S, European Research Council

Awards: Tlk Function and Regulation in Chromatin Replication and Tumor Suppression, G3665409236, G3693516624, G4383120653, G4598758285, G4768939348, G512875727, G5314256501, G6887303900, G7703175812

OpenAlex ID: W2886824412

FWCI: 1.726

Cites: 45

Cited by: 55

Related to: 10