Work

Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation

Year: 2018

Type: article

Abstract: Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expressed at higher levels in GALT compared to PBMC, whereas an opposite trend of expression was recorded for IFNγ. An increase of IFNα6, IFNα10, IFNα14, IFNα17, and IFNα21 and a decrease of IFNγ were observed in both anatomical sites after probiotic supplementation.

Source: Journal of Immunology Research

DOI: 10.1155/2018/1738676

Authors: Claudia Pinacchio, Giuseppe Corano Scheri, Maura Statzu, Letizia Santinelli, Giancarlo Ceccarelli, Giuseppe Pietro Innocenti, Vincenzo Vullo, Guido Antonelli, Jason M. Brenchley, Gabriella d’Ettorre, Carolina Scagnolari

Institutions: Sapienza University of Rome, Istituto Pasteur, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,830

Funders: Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Sapienza Università di Roma, Istituto Pasteur-Fondazione Cenci Bolognetti, National Institutes of Health, National Institute of Allergy and Infectious Diseases, NHLBI Division of Intramural Research

Awards: G1878687161, G2167359267, G2534842605, G280527145, G3772517896, G6293378640, G6632354779, G6661363943, G6775963593, G7749903543

OpenAlex ID: W2886870190

FWCI: 1.675

Cites: 22

Cited by: 20

Related to: 10