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Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species

Year: 2018
Type: article
Abstract: Alangium longiflorum is currently in extinction crisis, which will likely severely hamper further phytochemical investigation of this plant species from new collections. A crude extract of leaves of A. longiflorum (N33539), collected for the U.S. National Cancer Institute in 1989, showed potent cancer cell line antiproliferative activity. A phytochemical study resulted in the isolation of 17 secondary metabolites, including two new tetrahydroisoquinoline alkaloids, 8-hydroxytubulosine (1) and 2'- O- trans-sinapoylisoalangiside (2), as well as a new sinapolyloxylupene derivative (3). Using in-house assays and NCI-60 panel screening, compound 1 displayed broad-spectrum inhibitory activity at submicromolar levels against most tested tumor cell lines, except for drug-transporter-overexpressing cells. Compound 1 caused accumulation of sub-G1 cells with no effect on cell cycle progression, suggesting that this substance is an apoptosis inducer.
DOI: 10.1021/acs.jnatprod.8b00411
Authors: Misa Takeuchi, Yohei Saito, Masuo Goto, Katsunori Miyake, David J. Newman, Barry R. O’Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
Institutions: Kanazawa University, University of North Carolina at Chapel Hill, Tokyo University of Pharmacy and Life Sciences, National Institutes of Health, National Cancer Institute, Center for Cancer Research, China Medical University, China Medical University Hospital
Language: English
Subfield: Plant Science
Open Access status: green
Awards: G1534035308, Discovery of antitumor drug candidates from rainforest plants, Novel Antitumor Agents, G386607036, Development of novel drug leads based on rare tropical resources, G5888954722
OpenAlex ID: W2886977703
FWCI: 1.214
Cites: 23
Cited by: 11
Related to: 10