Year: 2018
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: CGG repeat size with manifestation, and severity of clinical symptoms of fragile X-associated tremor/ataxia syndrome (FXTAS). METHODS: messenger RNA were quantified and compared using analysis of variance. Least absolute shrinkage and selection operator (LASSO) logistic regression and receiver operating characteristic analyses were performed. RESULTS: -TV2 level (in women) were strongly associated with FXTAS compared with NC and PMC (combined). CONCLUSIONS: and loss of AGG interruptions in both men and women with FXTAS. Future studies will be needed to determine whether these variables can provide useful diagnostic or predictive information.
Source: Neurology Genetics
Authors: Padmaja Vittal, Shrikant Pandya, Kevin Sharp, Elizabeth Berry-Kravis, Lili Zhou, Bichun Ouyang, Jonathan Jackson, Deborah A. Hall
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,300
Funders: National Ataxia Foundation, Pfizer, American Brain Foundation, National Institutes of Health, Centers for Disease Control and Prevention, Parkinsonfonden, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W2887080972