Year: 2017
Type: dissertation
Abstract: During obesity, macrophages can infiltrate metabolic tissues and contribute to chronic low-grade inflammation as well as mediate insulin resistance and diabetes. Our study addresses the essential role of macrophage JAK2, a key mediator downstream of various cytokines, hormones and growth factors, in the pathogenesis to obesity and insulin resistance. Macrophage-specific JAK2 knockout (M-JAK2
Source: TSpace (University of Toronto)
Author: Harsh R. Desai
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2887083937