Work

Tuning of protease resistance in oligopeptides through N -alkylation

Year: 2018

Type: article

Abstract: N-Methylation of amino acids is an effective way to create protease resistance in both natural and synthetic peptides. However, alkyl substituents other than N-methyl have not been extensively studied. Here, we prepare and examine a series of N-substituted peptides in which the size and length of the alkyl group is modulated. These design insights provide a unique and modular handle for tuning proteolysis in oligopeptides.

Source: Chemical Communications

DOI: 10.1039/c8cc04407d

Authors: Revital Kaminker, Athina Anastasaki, Will R. Gutekunst, Yingdong Luo, Sang-Ho Lee, Craig J. Hawker

Institutions: University of California, Santa Barbara, University of California System

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green