Work

Please Stand By: How Oncolytic Viruses Impact Bystander Cells

Year: 2018

Type: review

Abstract: Oncolytic viruses (OVs) do more than simply infect and kill host cells. The accepted mechanism of action for OVs consists of a primary lytic phase and a subsequent antitumor and antiviral immune response. However, not all cells are subject to the direct effects of OV therapy, and it is becoming clear that OVs can also impact uninfected cells in the periphery. This review discusses the effects of OVs on uninfected neighboring cells, so-called bystander effects, and implications for OV therapies alone or in combination with other standard of care chemotherapy.

Source: Future Virology

DOI: 10.2217/fvl-2018-0068

Authors: Leslee Sprague, Lynne Braidwood, Joe Conner, Kevin A Cassady, Fabian Benencia, Timothy P Cripe

Institutions: The Ohio State University, Virttu Biologics (United Kingdom), Nationwide Children's Hospital, Ohio University

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ohio State University, Pelotonia, National Institutes of Health, National Institute of General Medical Sciences