Year: 2018
Type: article
Abstract: In mammals, the most striking IgA system belongs to Lagomorpha. Indeed, 14 IgA subclasses have been identified in European rabbits, 11 of which are expressed. In contrast, most other mammals have only one IgA, or in the case of hominoids, two IgA subclasses. Characteristic features of the mammalian IgA subclasses are the length and amino acid sequence of their hinge regions, which are often rich in Pro, Ser and Thr residues and may also carry Cys residues. Here, we describe a new IgA that was expressed in New Zealand White domestic rabbits of IGHVa1 allotype. This IgA has an extended hinge region containing an intriguing stretch of nine consecutive Ser residues and no Pro or Thr residues, a motif exclusive to this new rabbit IgA. Considering the amino acid properties, this hinge motif may present some advantage over the common IgA hinge by affording novel functional capabilities. We also sequenced for the first time the IgA14 CH2 and CH3 domains and showed that IgA14 and IgA3 are expressed.
Source: PLoS ONE
Institutions: Universidade do Porto, Centro de Investigação em Biodiversidade e Recursos Genéticos, Ludwig-Maximilians-Universität München, Commonwealth Scientific and Industrial Research Organisation, Loyola University Chicago, University of Dundee, Cooperativa de Ensino Superior Politécnico e Universitário, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: G1123992789, G1167214205, G1516346500, G1578237752, Evolução da virulência da Doença Hemorrágica Viral do coelho-bravo e mecanismos de resistência do hospedeiro., G1763632427, G274581676, G2793579600, G3057202055, G323769159, G3840324753, G4316116677, G4349168650, G4724859719, G5224927334, G5485649731, G5677667711, CIBIO - MEETING THE NEW SOCIETAL CHALLENGES ON AGRICULTURE, FOREST, ENVIRONMENT AND FOOD SECURITY, G7584003722, G7679394011, A DEFINIR DURANTE O PRIMEIRO ANO DO PROGRAMA DOUTORAL, G7965899483, G96847669
OpenAlex ID: W2887726655