Work

It’s All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies

Year: 2018

Type: article

Abstract: Hydrogels provide a regenerative medicine platform with their ability to create an environment that supports transplanted or endogenous infiltrating cells and enables these cells to restore or replace the function of tissues lost to disease or trauma. Furthermore, these systems have been employed as delivery vehicles for therapeutic genes, which can direct and/or enhance the function of the transplanted or endogenous cells. Herein, we review recent advances in the development of hydrogels for cell and non-viral gene delivery through understanding the design parameters, including both physical and biological components, on promoting transgene expression, cell engraftment, and ultimately cell function. Furthermore, this review identifies emerging opportunities for combining cell and gene delivery approaches to overcome challenges to the field.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2018.07.022

Authors: Richard L. Youngblood, Norman F. Truong, Tatiana Segura, Lonnie D. Shea

Institutions: University of Michigan, University of California, Los Angeles, Duke University

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500