Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity
Year: 2018
Type: article
Abstract: Centrosomes serve as the major microtubule organizing centers in cells and thereby contribute to cell shape, polarity, and motility. Also, centrosomes ensure equal chromosome segregation during mitosis. Centrosome aberrations arise when the centrosome cycle is deregulated, or as a result of cytokinesis failure. A long-standing postulate is that centrosome aberrations are involved in the initiation and progression of cancer. However, this notion has been a subject of controversy because until recently the relationship has been correlative. Recently, it was shown that numerical or structural centrosome aberrations can initiate tumors in certain tissues in mice, as well as invasion. Particularly, we will focus on centrosome amplification and chromosome instability as drivers of intra-tumor heterogeneity and their consequences in cancer. We will also discuss briefly the controversies surrounding this theory to highlight the fact that the role of both centrosome amplification and chromosome instability in cancer is highly context-dependent. Further, we will discuss single-cell sequencing as a novel technique to understand intra-tumor heterogeneity and some therapeutic approaches to target chromosome instability.
Institution: Ponce Health Sciences University
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: diamond
Awards: FUNCTIONAL ANALYSIS OF BRCA1 MUTANTS, RCMI Program at Ponce School of Medicine: Addressing Health Disparities, Puerto Rico Clinical and Translational Research Consortium (PRCTRC), Ponce_Health_Sciences_University_RISE_Graduate_Training_Program., G9000116377, 2/2 Ponce Health Sciences University-Moffitt Cancer Center Partnership, (1/2) Ponce Health Sciences University-Moffitt Cancer Center Partnership #
OpenAlex ID: W2887887183