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Adenine base editing to mimic or correct disease mutations in rodents

Year: 2018
Type: article
Abstract: mutations is clearly evident from the four studies, their specificity remains to be determined, especially in studies using unbiased genome-wide off-target detection platforms.Detection of base editor off-targets differs from that for CRISPR/Cas9 and presents its own challenges.A new methodology that can accurately and efficiently detect genome-wide off-targets of ABEs is therefore sorely needed.Only with such technologies can ABE specificity be properly and effectively improved.
DOI: 10.1007/s13238-018-0570-3
Institutions: Capital Medical University, Chinese Academy of Sciences, Xuan Wu Hospital of the Capital Medical University, Institute of Biophysics, University of Chinese Academy of Sciences, Salk Institute for Biological Studies
Language: English
Open Access status: gold
Estimated APC paid: $2,700
OpenAlex ID: W2887963652
FWCI:
Cites: 10
Cited by: 1
Related to: 10