Year: 2018
Type: editorial
Abstract: With the advent and increasing resolution of genome-wide sequencing modalities, alternative splicing (AS) has become an emerging area of interest in normal development and disease (1). Splicing of mRNA transcripts results in the production of a multitude of alternative isoforms from a single genomic locus, dramatically enhancing the diversity of the transcriptome and proteome (2). AS may affect RNA nuclear export and transcript stability, thereby regulating transcript levels. Distinct splicing isoforms may produce functionally equivalent, divergent, or inactive mature proteins (3).
Source: Stem Cell Investigation
Authors: Yimeng Gao, Radovan Vasic, Stephanie Halene
Institutions: Yale Cancer Center, Yale University
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2888171748