Work

Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18‐Seco‐Lankacidinol B

Year: 2018

Type: article

Abstract: Lankacidins are a group of polyketide natural products with activity against several strains of Gram-positive bacteria. We developed a route to stereochemically diverse variants of 2,18-seco-lankacidinol B and found that the stereochemical assignment at C4 requires revision. This has interesting implications for the biosynthesis of natural products of the lankacidin class, all of which possessed uniform stereochemistry prior to this finding. We have evaluated 2,18-seco-lankacidinol B and three stereochemical derivatives against a panel of pathogenic Gram-positive and Gram-negative bacteria.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201808612

Authors: Yanmin Yao, Lingchao Cai, Ian B. Seiple

Institution: University of California, San Francisco

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Center for Advancing Translational Sciences

Awards: Platforms for the Synthesis of Bacterial Protein Synthesis Inhibitors, Clinical and Translational Science Institute