Work

Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development

Year: 2018

Type: review

Abstract: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) has emerged as a key technology for label-free bioanalysis of the spatial distribution of biomolecules, pharmaceuticals and other xenobiotics in tissue sections. Recent advances in instrumentation, sample preparation, multimodal workflows, quantification, analytical standardization and 'big data' processing have led to widespread utilization of MALDI MSI in pharmaceutical research. These developments have led to applications of the technology in drug discovery beyond drug disposition analysis, most notably in pharmacodynamic biomarker research and in toxicology.

Source: Current Opinion in Biotechnology

DOI: 10.1016/j.copbio.2018.08.003

Authors: Sandra Schulz, Michael Becker, M. Reid Groseclose, Simone Schadt, Carsten Hopf

Institutions: Technische Hochschule Mannheim, Boehringer Ingelheim (Germany), GlaxoSmithKline (United States), F. Hoffmann-La Roche AG

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,530