Work

Emerging applications for DNA writers and molecular recorders

Year: 2018

Type: article

Abstract: Natural life is encoded by evolvable, DNA-based memory. Recent advances in dynamic genome-engineering technologies, which we collectively refer to as in vivo DNA writing, have opened new avenues for investigating and engineering biology. This Review surveys these technological advances, outlines their prospects and emerging applications, and discusses the features and current limitations of these technologies for building various genetic circuits for processing and recording information in living cells.

Source: Science

DOI: 10.1126/science.aat9249

Authors: Fahim Farzadfard, Timothy K. Lu

Institution: Massachusetts Institute of Technology

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: MIT Center for Integrative Synthetic Biology