Redox Signaling by Reactive Electrophiles and Oxidants
Year: 2018
Type: review
Abstract: The concept of cell signaling in the context of nonenzyme-assisted protein modifications by reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely complex topic that has been approached from numerous different and multidisciplinary angles. Our Review reflects on five aspects critical for understanding how nature harnesses these noncanonical post-translational modifications to coordinate distinct cellular activities: (1) specific players and their generation, (2) physicochemical properties, (3) mechanisms of action, (4) methods of interrogation, and (5) functional roles in health and disease. Emphasis is primarily placed on the latest progress in the field, but several aspects of classical work likely forgotten/lost are also recollected. For researchers with interests in getting into the field, our Review is anticipated to function as a primer. For the expert, we aim to stimulate thought and discussion about fundamentals of redox signaling mechanisms and nuances of specificity/selectivity and timing in this sophisticated yet fascinating arena at the crossroads of chemistry and biology.
Source: Chemical Reviews
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: Howard Hughes Medical Institute, Alfred P. Sloan Foundation, American Heart Association, Arnold and Mabel Beckman Foundation, Pershing Square Sohn Cancer Research Alliance, National Institutes of Health, Office of Naval Research, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, National Center for Research Resources, Division of Chemistry
Awards: G3429785529, G3452294746, G4378667772, Chemistry of Biological Systems, G5151707659, Posttranscriptional Redox Regulation in Cardiovascular Disease at the Whole-Transcriptome Scale, Deconvoluting Redox Biology with Targeted Chemistry, Acquisition of a Hybrid Quadrupole, Ion Mobility Separation, Orthogonal Accelerat, Central Control of Motoneurons, Zeiss LSM710 Confocal Microscope for Shared Imaging Facility
OpenAlex ID: W2889257276