Electrochemical Flash Fluorination and Radiofluorination
Year: 2018
Type: article
Abstract: A new method for rapid late‐stage fluorination using the cation pool technique is presented. Fluorination and no‐carrier‐added radiofluorination of methyl (phenylthio) acetate, methyl 2‐(methylthio) acetate, and methyl 2‐(ethylthio) acetate were performed. The carbocations formed through electrochemical oxidation were stabilized by using a divided electrochemical cell and 2,2,2‐trifluoroethanol (TFE) as the solvent at −20 °C. At the end of electrolysis, either stable‐isotope [19F]fluoride or no‐carrier‐added radioactive [18F]fluoride was added to the reaction mixture to form the fluorinated or radiofluorinated product.
Source: ChemElectroChem
Institution: University of California, Los Angeles
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
Awards: G2722652432, G9000011119
OpenAlex ID: W2889540314