Work

The opium poppy genome and morphinan production

Year: 2018

Type: article

Abstract: Poppy genome reveals evolution of opiates The opium poppy has been a source of painkillers since Neolithic times. Attendant risks of addiction threaten many today. Guo et al. now deliver a draft of the opium poppy genome, which encompasses 2.72 gigabases assembled into 11 chromosomes and predicts more than 50,000 protein-coding genes. A particularly complex gene cluster contains many critical enzymes in the metabolic pathway that generates the alkaloid drugs noscapine and morphinan. Science , this issue p. 343

Source: Science

DOI: 10.1126/science.aat4096

Authors: Li Guo, Thilo Winzer, Xiaofei Yang, Yi Li, Zemin Ning, Zhesi He, Roxana Teodor, Ying Lu, Tim A. Bowser, Ian A. Graham, Kai Ye

Institutions: First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, University of York, Wellcome Sanger Institute, Shanghai Ocean University, Fudan University

Language: English

Topic: Plant biochemistry and biosynthesis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, Garfield Weston Foundation, National Natural Science Foundation of China, Biotechnology and Biological Sciences Research Council

Awards: G3367199747, G4612446324, G4983681036, Understanding the regulation of alkaloid biosynthesis in opium poppy and breeding new varieties, G6544905218, G6685402819, G8199531049

OpenAlex ID: W2889545485

FWCI: 8.08

Cites: 78

Cited by: 342

Related to: 10