Work

Targeting Metalloenzymes for Therapeutic Intervention

Year: 2018

Type: review

Abstract: Metalloenzymes are central to a wide range of essential biological activities, including nucleic acid modification, protein degradation, and many others. The role of metalloenzymes in these processes also makes them central for the progression of many diseases and, as such, makes metalloenzymes attractive targets for therapeutic intervention. Increasing awareness of the role metalloenzymes play in disease and their importance as a class of targets has amplified interest in the development of new strategies to develop inhibitors and ultimately useful drugs. In this Review, we provide a broad overview of several drug discovery efforts focused on metalloenzymes and attempt to map out the current landscape of high-value metalloenzyme targets.

Source: Chemical Reviews

DOI: 10.1021/acs.chemrev.8b00201

Authors: Allie Y. Chen, Rebecca N. Adamek, Benjamin L. Dick, Cy V. Credille, Christine N. Morrison, Seth M. Cohen

Institution: University of California San Diego

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences