Peptide supramolecular materials for therapeutics
Year: 2018
Type: review
Abstract: Supramolecular assembly of peptide-based monomers into nanostructures offers many promising applications in advanced therapies. In this Tutorial Review, we introduce molecular designs to control the structure and potential biological function of supramolecular assemblies. An emphasis is placed on peptide-based supramolecular nanostructures that are intentionally designed to signal cells, either directly through the incorporation of amino acid sequences that activate receptors or indirectly by recruiting native signals such as growth factors. Additionally, we describe the use and future potential of hierarchical structures, such as single molecules that assemble into nanoscale fibers which then align to form macroscopic strings; the strings can then serve as scaffolds for cell growth, proliferation, and differentiation.
Source: Chemical Society Reviews
DOI: 10.1039/c7cs00735c
Institution: Northwestern University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Funders: National Science Foundation, U.S. Department of Energy, National Institutes of Health, National Heart, Lung, and Blood Institute, National Eye Institute, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Institute of Dental and Craniofacial Research, Division of Materials Research
Awards: Cardiovascular Regenerative Medicine, Nanomachinery of the Cytoskeleton (RMI), G222768804, Novel Vehicles for Targeted Cardiovascular Repair, NANOENGINEERING OF COMPLEX MATERIALS SUPRAMOLECULAR OBJECTS HYBRIDS AND BIOHYBRIDS, G391582027, TAS::89 0227::TAS RECOVERY; NEW: RECOVERY ACT - CENTER FOR INTEGRATED TRAINING IN FAR-FROM-EQUILIBRIUM AND ADAPTIVE MATERIALS (CITFAM) -- EFRC; PI -, Nanomaterials for Cancer Diagnostics and Therapeutics, Nanotechnology Strategies for Growth of Bones and Teeth, Bioactive Scaffolds for Regeneration in Spinal Cord Injury, NANOENGINEERING OF COMPLEX MATERIALS, Shape and Dimensional Precision in Polymeric Nanostructures
OpenAlex ID: W2889913341