Work

Inter-α inhibitor proteins maintain neutrophils in a resting state by regulating shape and reducing ROS production

Year: 2018

Type: article

Abstract: phosphorylation on Ser328. These results suggest that IAIP-induced morphological changes that render neutrophils quiescent, facilitate passage through the microvasculature, and reduce adhesion to vascular endothelial cells and production of ROS. Thus, IAIP plays a key role in controlling neutrophil activation.

Source: Blood Advances

DOI: 10.1182/bloodadvances.2018018986

Authors: Soe Soe Htwe, Hidenori Wake, Keyue Liu, Kiyoshi Teshigawara, Barbara S. Stonestreet, Yow-Pin Lim, Masahiro Nishibori

Institutions: Okayama University, Brown University, Women & Infants Hospital of Rhode Island, ProThera Biologics (United States)

Language: English

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,800

Funder: National Institute of Neurological Disorders and Stroke

Awards: Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury, Beneficial Effects of Inter-alpha Inhibitors in Fetal Brain Injury, Inter-alpha inhibitors: Novel neuroinflammatory modulator of neonatal brain injury

OpenAlex ID: W2889984138

FWCI: 1.825

Cites: 35

Cited by: 36

Related to: 10