Work

Heterogeneity in FoxP3- and GARP/LAP-Expressing T Regulatory Cells in an HLA Class II Transgenic Murine Model of Necrotizing Soft Tissue Infections by Group A Streptococcus

Year: 2018

Type: article

Abstract: Invasive group A streptococcus (GAS) infections include necrotizing soft tissue infections (NSTI) and streptococcal toxic shock syndrome (STSS). We have previously shown that host HLA class II allelic variations determine the risk for necrotizing fasciitis (NF), a dominant subgroup of NSTI, and STSS by modulating responses to GAS superantigens (SAgs).

Source: Infection and Immunity

DOI: 10.1128/iai.00432-18

Authors: Suba Nookala, Santhosh Mukundan, Alexander Fife, Jeyashree Alagarsamy, Malak Kotb

Institution: University of North Dakota

Language: English

Topic: Streptococcal Infections and Treatments

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of North Dakota, National Institute of General Medical Sciences