Work

Untersuchung der Funktionen der beiden switch-Regionen von RhoH bei der inhibitorischen Wirkung von RhoH in Phospholipase C-vermittelten Signalwegen

Year: 2017

Type: dissertation

Abstract: The atypical Rho-GTPase RhoH has shown altered expression in various forms of cancer. We investigated the structural conditions, especially the switch-regions, of the interaction of RhoH with Rac2, inhibiting the stimulation of the PLCγ¬2 and the PLCβ2, as well as of the suspected Rac2-independent inhibition of the PLC-enzymes by RhoH. Therefore we created different RhoH-mutants, which were subsequently expressed in Cos-7-cells together with a PLC and eventually Rac2, measuring the phosphoinositides produced by the PLC-enzymes.

Source: OPen Access Repositorium der Universität Ulm (OPARU) (Ulm University)

DOI: 10.18725/oparu-8056

Author: Nicola, Evelyne

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2890379489

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