Year: 2018
Type: review
Abstract: DNA mutations as a consequence of errors during DNA damage repair, replication, or mitosis are the substrate for evolution. In multicellular organisms, mutations can occur in the germline and also in somatic tissues, where they are associated with cancer and other chronic diseases and possibly with aging. Recent advances in high-throughput sequencing have made it relatively easy to study germline de novo mutations, but in somatic cells, the vast majority of mutations are low-abundant and can be detected only in clonal lineages, such as tumors, or single cells. Here we review recent results on somatic mutations in normal human and animal tissues with a focus on their possible functional consequences.
Source: Annual Review of Genetics
Authors: Lei Zhang, Jan Vijg
Institution: Albert Einstein College of Medicine
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
Awards: Integrative, age-related changes in genome and epigenome in human lung in relation to smoking, Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging, DNA Repair, Mutations and Cellular Aging, (PQB4) Age-cancer interplay of genome and epi-genome in human lung, G9000068001, G9000093672, G9000097876, Comparative genomics of longevity and Alzheimer's disease
OpenAlex ID: W2890388074