Work

Bovine Staphylococcus aureus Superantigens Stimulate the Entire T Cell Repertoire of Cattle

Year: 2018

Type: article

Abstract: infection. We determined the Vβ T cell activation profile for all functional SAgs encoded by RF122, revealing evidence for bovine host-specific activity among the recently identified RF122-encoded SAgs SElY and SElZ. Remarkably, we discovered that some strains have evolved the capacity to stimulate the entire T cell repertoire of cattle through an array of diverse SAgs, suggesting a key role in bovine immune evasion.

Source: Infection and Immunity

DOI: 10.1128/iai.00505-18

Authors: Gillian J. Wilson, Stephen W. Tuffs, Bryan A. Wee, Keun Seok Seo, Nogi Park, Timothy Connelley, Caitriona M. Guinane, W. Ivan Morrison, J. Ross Fitzgerald

Institutions: Roslin Institute, University of Glasgow, University of Edinburgh, Mississippi State University

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,177

Funders: Zoetis, Research Councils UK, Animal and Plant Quarantine Agency, National Institutes of Health, Directorate for Biological Sciences, Medical Research Council, Biotechnology and Biological Sciences Research Council, National Institute of General Medical Sciences

Awards: Innate immunity, Host-pathogen interactions, Pathogen diversity, host specificity and virulence, Pan-genome reverse vaccinology of Staphylococcus aureus bovine mastitis, G4043903716, G4804563127, G5208818359, G5241028474, G5438580958, G6249156886, Center of Biomedical Research Excellence in Pathogen Host Interactions, G6825224617, G7013216797, G8280934225, High resolution phylogenetic analysis of livestock-associated Staphylococcus aureus.

OpenAlex ID: W2890432321

FWCI: 6.041

Cites: 48

Cited by: 74

Related to: 10