Work

The Multifunctional Fungal Ergosterol

Year: 2018

Type: editorial

Abstract: The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are potential drug targets. In combination, those two reports strongly indicate that the biological relevance of ergosterol is broader than the current literature suggests.

Source: mBio

DOI: 10.1128/mbio.01755-18

Author: Marcio L. Rodrigues

Institutions: Universidade Federal do Rio de Janeiro, Instituto Carlos Chagas, Fundação Oswaldo Cruz

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900