Chromatin regulation and the histone code in HIV latency
Year: 2020
Type: article
Abstract: The formation of a latent reservoir of Human Immunodeficiency Virus (HIV) infection hidden from immune clearance remains a significant obstacle to approaches to eradicate HIV infection. Towards an understanding of the mechanisms of HIV persistence, there is a growing body of work implicating epigenetic regulation of chromatin in establishment and maintenance of this latent reservoir. Here we discuss recent advances in the field of chromatin regulation, specifically in our understanding of the histone code, and how these discoveries relate to our current knowledge of the chromatin mechanisms linked to HIV transcriptional repression and the reversal of latency. We also examine mechanisms unexplored in the context of HIV latency and briefly discuss current therapies aimed at the induction of proviral expression within latently infected cells. We aim to emphasize that a greater understanding of the epigenetic mechanisms which govern HIV latency could lead to new therapeutic targets for latency reversal and clearance cure strategies.
Source: Europe PMC (PubMed Central)
DOI: 10.17615/00r6-zn02
Authors: Turner, A.-M.W., Margolis, D.M.
Institution: University of North Carolina at Chapel Hill
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Collaboratory of AIDS Researchers for Eradication (CARE), A Pilot Trial of the effect of Vorinostat and AGS-004 on Persistent HIV-1 Infection, HIV-specific ex-vivo expanded T cell therapy (HXTC) to Deplete the Latent Reservoir of Persistent HIV Infection, Training in Sexually Transmitted Infections and HIV, The University of North Carolina Center for AIDS Research
OpenAlex ID: W4300997243