Work

Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures

Year: 2018

Type: article

Abstract: extrusion, without altering total or plasma membrane accumulation of KCC2. Critically, activity-induced deficits in synaptic inhibition were reduced in the mutant mice. Consistent with this, enhanced KCC2 was sufficient to limit chemoconvulsant-induced epileptiform activity. Furthermore, this increase in KCC2 function mitigated induction of aberrant high-frequency activity during seizures, highlighting depolarizing GABA as a key contributor to the pathological neuronal synchronization seen in epilepsy. Thus, our results demonstrate that potentiating KCC2 represents a therapeutic strategy to alleviate seizures.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1810134115

Authors: Yvonne E. Moore, Tarek Z. Deeb, Heramb Chadchankar, Nicholas J. Brandon, Stephen J. Moss

Institutions: Tufts University, University College London, AstraZeneca (United States)

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze