Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition
Year: 2018
Type: article
Study design: Observational Study
Abstract: Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one‐carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy‐adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (<241 μg/day) was 0.81 (95% CI: 0.51, 1.31; ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs. <241 μg/day, ptrend = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study.
Source: International Journal of Cancer
DOI: 10.1002/ijc.31830
Authors: Jin Young Park, H. Bas Bueno‐de‐Mesquita, Pietro Ferrari, Elisabete Weiderpass, Jordi de Batlle, Anne Tjønneland, Cecilie Kyro, Vinciane Rebours, Marie‐Christine Boutron‐Ruault, Francesca Romana Mancini, Verena Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Carlo La Vecchia, Maria Kritikou, Giovanna Masala, Valeria Pala, Rosario Tumino, Salvatore Panico, Petra H. Peeters, Guri Skeie, Susana Merino, Eric J. Duell, Miguel Rodríguez‐Barranco, Miren Dorronsoro, Maria‐Dolores Chirlaque, Eva Ardanaz, Björn Gylling, Jörn Schneede, Ulrika Ericson, Hanna Sternby, Kay‐Tee Khaw, Kathryn E. Bradbury, Inge Huybrechts, Dagfinn Aune, Paolo Vineis, Nadia Slimani
Institutions: Centre international de recherche sur le cancer, University Medical Center Utrecht, National Institute for Public Health and the Environment, Imperial College London, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway, Hospital Universitari Arnau de Vilanova, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Investigación Biomédica de Lleida, Danish Cancer Society, Inserm, Hôpital Beaujon, Centre de Recherche sur l'Inflammation, Université Paris-Sud, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, German Cancer Research Center, German Institute of Human Nutrition, Hellenic Health Foundation, University of Milan, Fondazione IRCCS Istituto Nazionale dei Tumori, Azienda Usl 8 Arezzo, Federico II University Hospital, University of Naples Federico II, Gobierno del Principado de Asturias, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Basque Government, Biogipuzkoa Health Research Institute, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Umeå University, Lund University, University of Cambridge, University of Oxford, Oslo Nye Høyskole, Italian institute for Genomic Medicine
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, Kræftens Bekæmpelse, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ligue Contre le Cancer, Vetenskapsrådet, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III
Awards: G1055973116, G1075502044, G1090603134, G1192877484, G1208621354, G1241080153, G1265254713, G1274701479, G1318397260, G1344656563, G1478484880, G1559294051, G172151099, G1767199718, G1788645866, G1907752718, G1952936224, G1993546569, G2027148636, G2131326840, G2149779140, G2149865848, G2216207056, G2235605558, G2257231888, G2336049343, G2372467518, G2409987178, G2539064604, G2561548287, G2572521044, G273148272, G2742323354, G2841678936, G2871896171, G29072894, G2924980845, G2999139090, G3010599472, G3049845011, G3077395769, G3170664214, G3189789075, G3216658785, G331404038, G3350062835, G3452641779, G3461390129, G3544161537, G3675143906, G3747421453, G375319704, G3816092139, G382879149, G3980646122, G4012977212, G4015156572, G4041385912, G4049848471, G4081633361, G4089957676, G4213141252, G423622538, G4303038735, G43956866, G4473162978, Health of vegetarians, G459595259, G4682079261, G4811780622, G4879533352, G490534113, G4913827001, G5004963360, G5047213743, G5119219000, G5375816427, G5406065712, G5456958854, G5578953934, G558017500, G5651954792, G569447510, G569908600, G5706284561, G5750710683, G5868006920, G5897142711, G5990830295, G6085534252, NIHR Senior Investigator Award, G6212483348, G6264211199, G6320156643, G640002926, G6442500046, G657255654, G6594529311, G6631454880, G6820515600, G6960682749, G7022277044, G7025202487, G7040807446, G7306252069, G7426181285, G7447125227, G7600088736, G7624991799, G7646326732, G7853538257, G7939399614, G8012318887, G8050896463, G817390530, G8279237360, G8331243404, G8374761964, G8407261631, G8508326818, G8525262851, G876765158, G8867963557, G8869854444, G8959392569, G8978728421, G9000332718
OpenAlex ID: W2890999151