Year: 2018
Type: article
Abstract: -permeable component of excitatory neurotransmission in the central nervous system (CNS). They are expressed throughout the CNS and play key physiological roles in synaptic function, such as synaptic plasticity, learning, and memory. NMDA receptors are also implicated in the pathophysiology of several CNS disorders and more recently have been identified as a locus for disease-associated genomic variation. NMDA receptors exist as a diverse array of subtypes formed by variation in assembly of seven subunits (GluN1, GluN2A-D, and GluN3A-B) into tetrameric receptor complexes. These NMDA receptor subtypes show unique structural features that account for their distinct functional and pharmacological properties allowing precise tuning of their physiological roles. Here, we review the relationship between NMDA receptor structure and function with an emphasis on emerging atomic resolution structures, which begin to explain unique features of this receptor.
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Awards: G1171762958, Structure and Function of Hetero-multimeric Glutamate Receptors, G2230881918, Gating and Permeation in Ionotropic Glutamate Receptors, G6402180200, Biomolecular Structure and Dynamics, G9000150638, G9000217385, G9000278148, Structures and reagents of NMDA receptors, Structural and functional investigation of allosteric NMDA receptor modulation, Graduate Training in the Pharmacological Sciences
OpenAlex ID: W2891053092