Work

Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells

Year: 2018

Type: review

Abstract: The advent of induced pluripotent stem cells (iPSCs) together with recent advances in genome editing, microphysiological systems, tissue engineering and xenograft models present new opportunities for the investigation of hematological diseases and cancer in a patient-specific context. Here we review the progress in the field and discuss the advantages, limitations, and challenges of iPSC-based malignancy modeling. We will also discuss the use of iPSCs and its derivatives as cellular sources for drug target identification, drug development and evaluation of pharmacological responses.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2018.02243

Authors: Huensuk Kim, Christoph Schaniel

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801