Work

Theranostics of Glioblastoma Multiforme: In Vitro Characterization of Targeted Nanoemulsions and Creation of a 3D Statistical Heatmap to Visualize Nanoemulsion Uptake

Year: 2015

Type: article

Abstract: Glioblastoma Multiforme (GBM) continues to be a leading form of malignant brain cancer. GBM presents a high variability patient to patient. This provides a need for a theranostic system capable of both delivering therapeutic and in real-time visually observe results. Current methods involve months between treatment application and available results. Based on Nemucore Medical Innovation’s drug delivery vehicles, nanoemulsions (NE) containing chemotherapeutics are being utilized to target cancer cells and reduce systemic toxicity. Through the automation of required statistical analysis and creation of a wire-frame rat brain model with 174 defined brain regions a software capable of providing ‘real-time’ pharmacodynamics analysis of Gd3+ annotated, receptor-targeted NE is one step closer.

Source: Digital WPI

Authors: Elizabeth Denise Lacarra, Jessica Meredith Sacks, Michael Day, Atieh Sadraei

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2891416665

FWCI:

Cites: 46

Cited by: 1

Related to: 10