Year: 2018
Type: article
Abstract: A novel inhibitor of N-linked glycosylation (NGI-1) inhibits the glycosylation and phosphorylation of multiple receptor tyrosine kinases in glioblastoma (GBM). NGI-1 sensitizes multiple models of GBM to chemotherapy and radiation in vitro and in vivo and may be especially effective in GBMs that retain active PTEN. See related article by Baro et al., p. 784
Source: Clinical Cancer Research
Authors: Daniel R. Wahl, Theodore S. Lawrence
Institution: University of Michigan
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2891542858