Year: 2018
Type: article
Abstract: Peripherally induced regulatory T (pT reg) cells play indispensable roles in regulating gut inflammation; however, the mechanism underling the differentiation of pT reg cells under inflammatory conditions remains largely unknown. Here, we show that the expression of Sox12, a member of SoxC family, is significantly induced in T reg cells in colitic mice. We also show that TCR–NFAT signaling induces Sox12 expression in CD4+ T cells. Although Sox12 is not required for the development of thymus-derived T reg (tT reg) cells, Sox12 is involved in the development of pT reg cells under inflammatory conditions in an adoptive transfer colitis model. Moreover, we found that enforced expression of Sox12 is sufficient to promote Foxp3 expression in CD4+ T cells even in the absence of TGF-β or IL-2 and that Sox12 binds to Foxp3 promoter and drives its transcription. These results suggest that TCR-NFAT signaling induces the development of pT reg cells in colitic mice partly through Sox12 induction.
DOI: 10.1084/jem.20172082
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Awards: The role of IL-33-ILCs axis in the development of autoimmune arthritis, G1777002798, Role of Sox molecules in the development of autoimmune diseases, Comprehensive analysis of airway epithelial cell-dendritic cell interactions in allergen sensitization, The regulation of IkBNS in goblet cell differentiation in asthma, Role of Sox transcription factors in the onset of autoimmune diseases
OpenAlex ID: W2891645375