Work

Characterization of a Swine (Sus scrofa) Model of Oral Potassium Cyanide Intoxication

Year: 2018

Type: article

Abstract: test was used to calculate confidence intervals, mean, and standard deviation, and a Kaplan-Meier survival curve was used to compare survival between the 2 groups. At baseline, all animals in both groups were similar. Animals in the 5-mg/kg group had a more rapid time to apnea (5.1 ± 2.1 min), longer time to death (48.5 ± 38.1 min), and a greater rate of survival than the 8-mg/kg group (apnea, 10.6 ± 10.7 min; death, 26.1 ± 5.8 min). All animals displayed signs of toxicity (acidemia, hyperlactatemia, hypotension, apnea). We here report a large animal (swine) model of oral cyanide poisoning with dose-dependent effects in regard to time to death and survival rate. This model likely will be valuable for the development of medical countermeasures for oral cyanide poisoning.

Source: Comparative Medicine

DOI: 10.30802/aalas-cm-18-000041

Authors: Patrick C Ng, Tara B Hendry-Hofer, Alyssa E Witeof, Matthew Brenner, Sari B Mahon, Gerry R Boss, Vikhyat S Bebarta

Institutions: Denver Health Medical Center, University of Colorado Anschutz, University of California, Irvine, Beckman Laser Institute and Medical Clinic, University of California San Diego

Language: English

Topic: Poisoning and overdose treatments

Subfield: Emergency Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2891824826

FWCI: 1.833

Cites: 18

Cited by: 8

Related to: 10