Work

Superresolution Diffuse Optical Imaging by Localization of Fluorescence

Year: 2018

Type: article

Abstract: Diffuse optical imaging has strong potential for $i\phantom{\rule{0}{0ex}}n$ $v\phantom{\rule{0}{0ex}}i\phantom{\rule{0}{0ex}}v\phantom{\rule{0}{0ex}}o$ and deep-tissue applications in medicine, but has been hampered by low spatial resolution. The authors present a superresolution method for diffuse optical imaging that is based on point localization in a diffusion framework, and they demonstrate an improvement in resolution of over two orders of magnitude when imaging fluorescence. This approach will enable optical imaging through centimeters of tissue, at a resolution of tens of microns.

Source: Physical Review Applied

DOI: 10.1103/physrevapplied.10.034021

Authors: Brian Z. Bentz, Dergan Lin, Kevin J. Webb

Institutions: Purdue University West Lafayette, Sandia National Laboratories

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Science Foundation, U.S. Department of Energy, National Institutes of Health, National Cancer Institute

Awards: CIF: Small: Fast In Vivo Optical Imaging in the Heavily and Weakly Scattering Regimes, Optical Imaging of Targeted Anti-Cancer Drug Delivery Kinetics