Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity: LIFE‐Moms Prospective Meta‐Analysis
Year: 2018
Type: article
Study designs: Systematic Review, Meta-Analysis
Abstract: OBJECTIVE: This study aimed to evaluate the effects of varied lifestyle intervention programs designed to ameliorate excess gestational weight gain (GWG) in pregnant women with overweight or obesity compared with standard care, including effects on pregnancy outcomes. METHODS: Seven clinical centers conducted separate randomized clinical trials to test different lifestyle intervention strategies to modify GWG in diverse populations. Eligibility criteria, specific outcome measures, and assessment procedures were standardized across trials. The results of the separate trials were combined using an individual-participant data meta-analysis. RESULTS: For the 1,150 women randomized, the percent with excess GWG per week was significantly lower in the intervention group compared with the standard care group (61.8% vs. 75.0%; odds ratio [95% CI]: 0.52 [0.40 to 0.67]). Total GWG from enrollment to 36 weeks' gestation was also lower in the intervention group (8.1 ± 5.2 vs. 9.7 ± 5.4 kg; mean difference: -1.59 kg [95% CI:-2.18 to -0.99 kg]). The results from the individual trials were similar. The intervention and standard care groups did not differ in preeclampsia, gestational diabetes, cesarean delivery, or birth weight. CONCLUSIONS: Behavioral lifestyle interventions focusing primarily on diet and physical activity among women with overweight and obesity resulted in a significantly lower proportion of women with excess GWG. This modest beneficial effect was consistent across diverse intervention modalities in a large, racially and socioeconomically diverse US population of pregnant women.
Source: Obesity
DOI: 10.1002/oby.22250
Authors: Alan M. Peaceman, Rebecca G. Clifton, Suzanne Phelan, Dympna Gallagher, Mary Evans, Leanne M. Redman, William C. Knowler, Kaumudi Joshipura, Debra Haire‐Joshu, Susan Z. Yanovski, Kimberly A. Couch, Kimberly L. Drews, Paul W. Franks, Samuel Klein, Corby K. Martin, Xavier Pi‐Sunyer, Elizabeth A. Thom, Linda Van Horn, Rena R. Wing, Alison G. Cahill
Institutions: Northwestern University, George Washington University, California Polytechnic State University, Columbia University Irving Medical Center, Columbia University, National Institute of Diabetes and Digestive and Kidney Diseases, Pennington Biomedical Research Center, Harvard University, University of Puerto Rico, Medical Sciences Campus, Washington University in St. Louis, Indian Health Service, Phoenix Indian Medical Center, Lund University, Skåne University Hospital, Brown University
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Novo Nordisk Fonden, National Institutes of Health, Indian Health Service, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development, National Center for Research Resources, Office of Disease Prevention, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities, National Center for Complementary and Integrative Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1243117390, G1465098395, G1493458477, G1546933035, G2099266705, G2222671754, G3345799211, G410555167, G413336477, G4462311993, G4679850922, G488679904, G523707067, G6122681063, Pregnancy and EARly Lifestyle improvement Study (PEARLS), G645702072, Maternal-Offspring Metabolics: Family Intervention Trial (MOMFIT), Weight Management in Obese Pregnant Underserved African American Women, G70346534, Puerto Rico Clinical and Translational Research Consortium (PRCTRC), G799249705, Expecting Success: Personalized management of body weight during pregnancy, G820734021, Lifestyle Interventions in Overweight and Obese Pregnant Women, G9000003246, G9000008317, G9000036907, G9000061788, G9000083019, G9000090439, G9000092754, G9000133560, G9000151245, G9000271159, G9000311072, The Washington University Center for Diabetes Translation Research, Washington University Nutrition Obesity Research Center, Washington University Institute of Clinical and Translational Sciences, Louisiana Clinical and Translational Science Center
OpenAlex ID: W2891994906