Functional Conservation of P48/45 Proteins in the Transmission Stages ofPlasmodium vivax(Human Malaria Parasite) andP. berghei(Murine Malaria Parasite)
Year: 2018
Type: article
Abstract: Malaria transmission depends upon successful sexual differentiation and maturation of parasites in the vertebrate host and further development in the mosquito midgut. Stage-specific proteins in the sexual stages have been shown to play a critical role in development and successful transmission through the anopheline mosquito vector. Studies presented in the current manuscript evaluated functional conservation of one such protein, P48/45, in two diverse species ( P. berghei and P. vivax ). Replacement of endogenouspbs48/45in P. berghei withpvs48/45( P. vivax homologue) did not affect the viability of the parasites, and the transgenic parasites expressing Pvs48/45 remained transmission competent. These studies establish not only the functional conservation of P48/45 in P. berghei and P. vivax but also offer an opportunity to develop anin vivotest model for Pvs48/45-based P. vivax transmission-blocking vaccines, currently under development.
Source: mBio
Institution: Tulane University
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
OpenAlex ID: W2892035374