Year: 2018
Type: article
Abstract: Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.
Source: The Journal of Headache and Pain
Institutions: University of Copenhagen, Glostrup Hospital, Rigshospitalet, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Sapienza University of Rome, Erasmus MC, University of Palermo, University of Modena and Reggio Emilia, University of Perugia, Ordensklinikum Linz Barmherzige Schwestern
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,990
Award: G675331030
OpenAlex ID: W2892050951