Work

9-cis-Retinoic Acid and 1,25-dihydroxy Vitamin D3 Improve the Differentiation of Neural Stem Cells into Oligodendrocytes through the Inhibition of the Notch and Wnt Signaling Pathways.

Year: 2018

Type: article

Abstract: BACKGROUND: ) can ameliorate oligodendrogenesis. We investigated whether they could increase oligodendrogenesis by inhibiting the Wnt and Notch signaling pathways. METHODS: on the level of the myelin basic protein (MBP) and the gene expression of the SOX10, MBP gene, HES5, and LRP6 were studied using flow cytometry and real-time PCR. The data were analyzed using one-way ANOVA with GraphPad Prism. A P value less than 0.05 was considered significant. RESULTS: significantly reduced the expression of the LRP6 gene, a Wnt signaling pathway co-receptor. CONCLUSION: are good candidates to improve the differentiation of OPCs into oligodendrocytes.

Source: Europe PMC (PubMed Central)

Authors: Saeedeh Saeb, Hassan Azari, Zohreh Mostafavi-Pour, Amir Ghanbari, Sepideh Ebrahimi, Pooneh Mokarram

Institutions: Shiraz University of Medical Sciences, Yasuj University of Medical Sciences

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2892063815

FWCI: 0.446

Cites: 40

Cited by: 8

Related to: 10